Novel Bone Void Filling Cement Compositions Based on Shell Nacre and Siloxane Methacrylate Resin: Development and Characterization

Shell nacre from Pinctada species has been extensively researched for managing bone defects. However, there is a gap in the research regarding using shell powder as cement with improved biological and physicochemical properties. To address this, void filling was formulated by incorporating an organically modified ceramic resin (ormocer). The specifically processed shells of fucata analysed thermogravimetric analysis (TGA), X-ray diffraction spectroscopy, Fourier transform infrared (FTIR), Raman confirming presence organic constituents inorganic aragonite. Trace element confirmed eligibility biomedical applications. Next, ormocer SNLSM2 synthesized through sol–gel method. FTIR, Raman, TGA, transmission electron microscopy studies revealed ladder-structured siloxane backbone methacrylate side chain. develop chemical curable composite (SNC), different amounts (24%, 48%, 72%) were added to resin, impact on properties studied. Among compositions, SNC 72 exhibited significantly lower linear polymerization shrinkage (0.4%) higher compressive (>100 MPa) flexural strength (>35 MPa). radiopaque, exotherm generated during curing minimal. Cytotoxicity L929 cells non-cytotoxic nature cement. Overall, findings this study prove that promising candidate voids.